Avilamycinbelongs rau chav kawm orthosomycin ntawm antimicrobial.Avilamycinyog nquag nquag tawm tsam gram zoo kab mob. Cov kab mob, zoo li tag nrho cov nyob hauv hlwb, tas li ua cov proteins kom tswj cov cellular muaj nuj nqi suav nrog cell replication. Qhov no kuj suav nrog DNA replication uas yuav tsum tau ua ua ntej cell replication tuaj yeem tshwm sim. Protein synthesis yog txheej txheem uas tshwm sim ntawm ribosome pom hauv cov kab mob.
Avilamycininhibits protein synthesis los ntawm ib tug tshiab ob mechanism ntawm kev txiav txim. Ua ntej, los ntawm kev thaiv cov theem pib ntawm cov protein synthesis. Thiab qhov thib ob, los ntawm kev thaiv cov theem lig ntawm cov protein synthesis. Yog li, inhibiting protein synthesis uas ua rau cov kab mob tuag.
Ribosomes yog tsim los ntawm ob subunits: 30s thiab 50s. Thiab qhov no yog cov tshuab hauv cov hlwb uas yog lub luag haujlwm rau kev sib sau cov protein ib leeg hu ua amino acid rau hauv cov protein ntau. Lub 30s thiab 50s ua hauj lwm raws li ib pab pawg neeg los nyeem cov noob caj noob ces thiab sib sau ua ke cov amino acids feem rau hauv cov protein ua haujlwm. Qhov tseem ceeb, nyob rau hauv thawj kauj ruam ntawm protein synthesis mRNA muab ib tug tshwj xeeb genetic code rau 30S ribosomal subunit. Thaum nyob rau theem thib ob ntawm kev tsim cov protein, tRNA xa cov amino acid blocks rau 50s ribosomal subunit.
Avilamycinkhi rau ob lub 30s thiab 50s subunits thiab blocks protein synthesis nyob rau hauv cov kev txiav txim hauv qab no:
Los ntawm kev txuas mus rau 30s, Avilamycin tiv thaiv kev nyeem cov kab mob caj ces los ntawm mRNA
Los ntawm kev txuas mus rau 50s, Avilamycin tiv thaiv cov amino acid sib dhos los ntawm tRNA
Cov chaw sib txuas ntawmAvilamycinntawm ribosome yog txawv ntawm cov siv los ntawm lwm yam tshuaj tua kab mob uas kuj yog protein synthesis inhibitors. Piv txwv li, cov tshuaj tua kab mob xws li Virginiamycin, uas tseem yog cov protein synthesis inhibitor, tsuas muaj ib hom kev ua uas lawv tsuas khi rau ib qho chaw sib txawv ntawm 50s ribosomal subunit. Qhov no piav qhia txog qhov tsis muaj kev tiv thaiv ntawm Avilamycin thiab lwm yam tshuaj tua kab mob uas inhibit protein synthesis.
Avilamycininhibits protein synthesis los ntawm ib tug tshiab ob mechanism ntawm kev txiav txim. Ua ntej, los ntawm kev thaiv cov theem pib ntawm cov protein synthesis. Thiab qhov thib ob, los ntawm kev thaiv cov theem lig ntawm cov protein synthesis. Yog li, inhibiting protein synthesis uas ua rau cov kab mob tuag.
