I. Osmotic diuretic nyhuv
1. Ua kom plasma osmolality:
Mannitol yog ib hom tshuaj hypertonic uas ua rau cov ntshav osmolality sai sai tom qab txhaj tshuaj.
Raws li muaj ib qho osmotic siab gradient ntawm cov ntshav thiab lub raum tubular kua, qhov no ua rau kev hloov dej ntawm lub raum tubular kua rau plasma, yog li txo cov tubular reabsorption ntawm thawj cov zis.
2. Ua kom cov ntshav ntim thiab lub raum ntshav khiav:
Mannitolnce ntshav ntim, uas nyob rau hauv lem ua rau kom cov ntshav khiav.
Qhov no yuav pab ua kom lub glomerular pom tus nqi, tso cai rau ntau cov dej thiab cov kuab tshuaj kom lim tawm ntawm glomeruli.
3. Inhibits tubular reabsorption ntawm dej thiab electrolytes:
Hauv txhua ntu ntawm lub raum tubule, mannitol inhibits reabsorption ntawm dej thiab electrolytes xws li sodium ions los ntawm nws cov nyhuv hypertonic.
Tshwj xeeb tshaj yog nyob rau hauv tuab ntu ntawm ceg nce toj ntawm Henry lub collaterals thiab proximal tubule, cov nyhuv ntawm mannitol yog ntau pronounced, uas ua rau muaj zog diuretic nyhuv.
II. Cov ntaub so ntswg dehydration cuam tshuam
1. Txo cov kua cerebrospinal ntau lawm:
Thaum mannitol nkag mus rau hauv cov kua cerebrospinal los ntawm cov ntshav - lub hlwb barrier, nws ua rau lub siab osmotic ntawm cov kua cerebrospinal.
Qhov no tso cai rau cov dej hauv cov kua cerebrospinal hloov mus rau cov ntshav, yog li txo cov kua cerebrospinal tsim thiab txo qis intracranial siab.
2. Txo cov ntaub so ntswg edema:
Rau cov ntaub so ntswg hauv zos, xws li cerebral edema thiab pulmonary edema, mannitol induces hloov dej ntawm cov ntaub so ntswg interstitium mus rau cov hlab ntsha los ntawm kev ua kom cov osmolality ntawm cov ntaub so ntswg hauv zos.
Qhov no txo cov nqaij edema thiab txhim kho cov ntshav ncig thiab kev ua haujlwm ntawm cov ntaub so ntswg hauv zos.
Hais txog peb
Gnee Chemtau tsim nyob rau lub Peb Hlis 2014.
Lub tuam txhab tshwj xeeb hauv kev lag luam thoob ntiaj teb kev lag luam thiab tau teeb tsa nws txoj kev ua lag luam thoob ntiaj teb.
Lub tuam txhab muaj ntau xyoo dhau los ntawm kev tsim thiab muag cov khoom zoo - cov tshuaj zoo, muab cov tshuaj organic, biochemicals, tshuaj intermediates thiab lwm yam khoom.
Peb muaj ib pab neeg R & D uas txawj ntse heev. Peb pab neeg ntawm ntau tshaj 200 tus neeg yog lub luag haujlwm rau ib qho - nres kev pabcuam ntawm kev tshuaj xyuas zoo, kev tswj xyuas ntau lawm thiab tom qab- kev pabcuam muag. Peb muab R & D thiab cov kev daws teeb meem rau peb cov neeg siv khoom thoob ntiaj teb.
