Lamivudine, feem ntau hu ua 3TC, yog ib hom tshuaj tiv thaiv kab mob uas siv los tiv thaiv thiab kho HIV/AIDS. Nws kuj tseem siv los kho tus kab mob siab B mob ntev thaum lwm yam kev xaiv tsis tuaj yeem ua tau. Nws muaj txiaj ntsig tiv thaiv kab mob HIV-1 thiab HIV-2.
SAN ANTONIO - Kev tshawb nrhiav kev sim coj los ntawm cov kws tshawb fawb los ntawm University of Texas Health Science Center ntawm San Antonio (UT Health San Antonio) qhia cov lus cog tseg rau cov neeg uas muaj kev txawj ntse me ntsis hloov kho nroglamivudine, Food and Drug Administration- pom zoo tshuaj tiv thaiv kab mob. Txoj kev tshawb no qhia txog kev txhim kho tseem ceeb hauv neurodegeneration thiab o.
A. Campbell Sullivan, PsyD, ABPP-CN, tus kws tshaj lij kws kho mob hauv chav haujlwm neurology ntawm Biggs Institute thiab tus kws tshawb fawb tau hais tias "Nws yog lub sijhawm zoo siab rau Alzheimer's kev tshawb fawb nrog ntau qhov kev sim siab uas yuav tawm los," said A. Campbell Sullivan, PsyD, ABPP "Tus kab mob- hloov kho kev kho dementia muaj tsawg thiab tuaj yeem muaj kev cuam tshuam loj heev. Peb cov txiaj ntsig tau pom tias kev kho mob nroglamivudinemuaj kev nyab xeeb thiab qhia tias muaj txiaj ntsig zoo rau cov neeg muaj kab mob Alzheimer thaum ntxov. "
Txoj kev tshawb no suav nrog 12 tus neeg koom nrog, hnub nyoog 52 txog 83 xyoos, nrog kev paub tsis meej me ntsis. Lawv muab tso raulamivudinerau rau lub hlis nrog cov ntshav thiab cov kua cerebrospinal sau ntawm lub hauv paus thiab tom qab txiav kev kho mob mus kawm biomarkers. Cerebrospinal kua yog cov kua nyob ib ncig ntawm lub hlwb thiab tus txha caj qaum. Cov kua dej ua haujlwm ua lub ncoo rau lub hlwb thiab tus txha caj qaum thiab pab cov kws kho mob txheeb xyuas lossis txiav txim tawm ntau yam kab mob.
Kev mob tshwm sim
LamivudineFeem ntau yog cov tshuaj muaj kev nyab xeeb, muaj kev phiv tsawg dua li lwm cov nucleoside thim rov qab transcriptase inhibitors (NRTIs). Nws cov kev mob tshwm sim feem ntau yog mob taub hau, qaug zog, thiab xeev siab uas feem ntau ploj mus dhau sijhawm. Lwm cov kev mob tshwm sim muaj xws li txo qis qab los noj mov, raws plab, ua pob khaus tawv nqaij, thiab mob plab. Kev xeev siab thiab raws plab tuaj yeem tswj tau nrog lwm cov tshuaj, uas tuaj yeem muab tshuaj ua ntej pib lamivudine. Lamivudine cov kev mob tshwm sim feem ntau tshwm sim thaum lub sij hawm ntxov ntawm kev kho mob.
Hauv cov neeg uas muaj HIV/HBV co- kis kab mob, txiav tawm ntawmlamivudinetej zaum yuav ua rau muaj qhov kub hnyiab- nce tus kab mob siab B. Ua tib zoo saib xyuas cov tib neeg no raug qhia.
Tsawg cov kev mob tshwm sim ntawmlamivudineCov kab mob pancreatitis (feem ntau yog nyob rau hauv cov kab mob siab heev), peripheral neuropathy, anemia, txo qis neutrophil suav, nce siab enzymes, rog redistribution, neutropenia (cov qe ntshav dawb tsawg) thiab ua pob liab liab. Kuj tseem muaj cov lus ceeb toom ntawm cov plaub hau poob, mob ntshav qab zib hnyav thiab lactic acidosis (kev nce qib ntawm lactic acid hauv cov ntshav) ntawm cov neeg tau txais lamivudine.
